Anti-ACE2 Antibody

Primary Antibodies

92463 MW

WB: 1-2 μg/mL; IHC: 2 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human samples; Immunofluorescence in human and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Processed angiotensin-converting enzyme 2:
Secreted.

Expressed in endothelial cells from small and
large arteries, and in arterial smooth muscle cells. Expressed in
lung alveolar epithelial cells, enterocytes of the small
intestine, Leydig cells and Sertoli cells (at protein level).
Expressed in heart, kidney, testis, and gastrointestinal system.

Anti-ACE2 has no cross response to ACE1.