Anti-PRMT1 Antibody

Primary Antibodies

42462 MW

WB: 1:500-1:1, 000
ICC: 1:100-1:500
IHC: 1:50-1:200

Protein arginine N-methyltransferase 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Arginine methyltransferase that methylates (mono and
asymmetric dimethylation) the guanidino nitrogens of arginyl
residues present in proteins such as ESR1, histone H2, H3 and H4,
PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and
SERBP1 (PubMed:16879614, PubMed:26876602). Constitutes the main
enzyme that mediates monomethylation and asymmetric dimethylation
of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a
specific tag for epigenetic transcriptional activation. Together
with dimethylated PIAS1, represses STAT1 transcriptional activity,
in the late phase of interferon gamma (IFN-gamma) signaling. May
be involved in the regulation of TAF15 transcriptional activity,
act as an activator of estrogen receptor (ER)-mediated
transactivation, play a key role in neurite outgrowth and act as a
negative regulator of megakaryocytic differentiation, by
modulating p38 MAPK pathway. Methylates RBM15, promoting
ubiquitination and degradation of RBM15 (PubMed:26575292).
Methylates FOXO1 and retains it in the nucleus increasing its
transcriptional activity. Methylates CHTOP and this methylation is
critical for its 5-hydroxymethylcytosine (5hmC)-binding activity
(PubMed:25284789). Methylates H4R3 in genes involved in
glioblastomagenesis in a CHTOP- and/or TET1-dependent manner
(PubMed:25284789).

Boster Bio Anti-PRMT1 Antibody catalog # A01417-2. Tested in WB, ICC/IF, IHC, CHIP applications. This antibody reacts with Human, Mouse, Rat.