Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4)

Primary Antibodies, Mouse Monoclonal Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

122102 MW

Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human
Immunohistochemistry (Frozen Section), 2-4μg/ml, Human

Mucin-1

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Add 1 ml of PBS buffer will yield a concentration of 100ug/ml.

Cancer, Cell Type Markers, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tags & Cell Markers, Tumor Associated, Tumor Immunology, Tumor-Associated Antigens

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.

Boster Bio Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4) catalog # MA1039. Tested in IHC applications. This antibody reacts with Human.

Contains 1 SEA domain.