Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

40524 MW

Western blot, 0.1-0.5?g/ml, Human

Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells, Human

C-C chemokine receptor type 5

Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40, 600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Alzheimer's Disease, Antiviral Signaling, Atherosclerosis, Cancer, Cardiovascular, Chemokines, G Protein Signaling, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interspecies Interaction, Macrophage/Inflammation, Microbiology, Neurodegenerative Disease, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vascular Inflammation

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Boster Bio Anti-C-C chemokine receptor type 5 CCR5 Antibody catalog # PA1016-1. Tested in Flow Cytometry, WB applications. This antibody reacts with Human.

Belongs to the G-protein coupled receptor 1 family.