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Anti-Myelin Basic Protein/MBP Antibody Picoband®

Anti-Myelin Basic Protein/MBP Antibody Picoband®

Item no.	BOS-PA1050
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot Primary Antibodies Adhesion Molecule Markers Astrocyte Markers
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IF, IHC
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Marty MC, Alliot F, Rutin J, Fritz R, Trisler D, Pessac B.The myelin basic protein gene is expressed in differentiated blood cell lineages and in hemopoietic progenitors. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8856-61. 2. Streicher R, Stoffel W.The organization of the human myelin basic protein gene. Comparison with the mouse gene. Biol Chem Hoppe Seyler. 1989 May; 370(5):503-10. 3. McLaurin JA, Hafler DA, Antel JP.Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter. J Neurol Sci. 1995 Feb; 128(2):205-11. 4. Iester A, Vignola S, Callegarini L, Gimelli G, Alpigiani MG. [18q syndrome with deficiency of myelin basic protein (MBP)] Pediatr Med Chir. 1996 Mar-Apr; 18(2):201-5. 5. Tranquill LR, Skinner E, Campagnoni C, Vergelli M, Hemmer B, Muraro P, Martin R, McFarland HF, Campagnoni AT, Voskuhl RR. Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic protein: recognition of golli MBP HOG 7. J Neurosci Res. 1996 Sep 15; 45(6):820-8.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Myelin basic protein;MBP;Myelin A1 protein;Myelin membrane encephalitogenic protein;MBP;
Similar products	GDB antibody, Golli MBP antibody, Hemopoietic MBP antibody, HMBPR antibody, HUGO antibody, MBP antibody, MBP_HUMAN antibody, MGC99675 antibody, MLD antibody, Myelin A1 Protein antibody, Myelin basic protein antibody, Myelin Deficient antibody, Myelin Membrane Encephalitogenic Protein antibody, OTTHUMP00000163776 antibody, OTTHUMP00000174387 antibody, OTTHUMP00000174388 antibody, SHI antibody, Shiverer antibody, SP antibody
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	17-33 kDa
Calculated Molecular weight	33117 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Mouse, Rat, By Heat Immunofluorescence, 2?g/ml, Mouse, Rat
Manufacturer - Gene Name	MBP
Gene Full Name	Myelin basic protein
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Myelin basic protein (MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Myelin Basic Protein, identical to the related rat and mouse sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.01mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Tags & Cell Markers
Protein Name	Myelin basic protein(MBP)
Protein Function	The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Subcellular Localization	Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.
Description	Boster Bio Anti-Myelin Basic Protein/MBP Antibody catalog # PA1050. Tested in IF, IHC, WB applications. This antibody reacts with Mouse, Rat.
Tissue Specificity	MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Sequence Similarities	Belongs to the myelin basic protein family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1050-datasheet.pdf

BOS-PA1050-safety-datasheet.pdf