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Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody Picoband®

Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody Picoband®

Item no.	BOS-PA1504
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Hematology Myeloma Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies By Organ Heart & Blood Cancer Lymphatic System Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. Ruland, J., Duncan, G. S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A., Ohashi, P. S., Mak, T. W.Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa-B and neural tube closure.Cell 104: 33-42, 2001. 2. Willis, T. G., Jadayel, D. M., Du, M.-Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P. G., Dyer, M. J. S.Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor typesCell 96: 35-45, 1999. 3. Xue, L., Morris, S. W., Orihuela, C., Tuomanen, E., Cui, X., Wen, R., Wang, D.Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.Nature Immun. 4: 857-865, 2003.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B-cell lymphoma/leukemia 10;B-cell CLL/lymphoma 10;Bcl-10;CARD-containing molecule enhancing NF-kappa-B;CARD-like apoptotic protein;hCLAP;CED-3/ICH-1 prodomain homologous E10-like regulator;CIPER;Cellular homolog of vCARMEN;cCARMEN;Cellular-E10;c-E10;Mammalian CARD-containing adapter molecule E10;mE10;BCL10;CIPER, CLAP;
Similar products	cE10 antibody, AI132454 antibody, B cell CLL/lymphoma 10 antibody, B cell lymphoma/leukemia10 antibody, B-cell CLL/lymphoma 10 antibody, B-cell leukemia/lymphoma 10 antibody, B-cell lymphoma/leukemia 10 antibody, Bcl 10 antibody, Bcl-10 antibody, Bcl10 antibody, BCL10_HUMAN antibody, c E10 antibody, c-E10 antibody, C81403 antibody, CARD containing apoptotic signaling protein antibody, CARD containing molecule enhancing NF kappa B antibody, CARD containing molecule enhancing NF kB antibody, CARD containing molecule enhancing NF-kB antibody, CARD containing molecule enhancing NFkB antibody, CARD containing proapoptotic protein antibody, CARD like apoptotic protein antibody, CARD-containing apoptotic signaling protein antibody, CARD-containing molecule enhancing NF-kappa-B antibody, CARD-containing proapoptotic protein antibody, CARD-like apoptotic protein antibody, CARMEN antibody, Caspase recruiting domain containing protein antibody, caspase-recruiting domain-containing protein antibody, cCARMEN antibody, cE 10 antibody, CED 3/ICH 1 prodomain homologous E10 like regulator antibody, CED-3/ICH-1 prodomain homologous E10-like regulator antibody, CED3/ICH1 prodomain homologous E10 like regulator antibody, Cellular E10 antibody, Cellular homolog of vCARMEN antibody, Cellular-E10 antibody
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	37 kDa
Calculated Molecular weight	26252 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse
Manufacturer - Gene Name	BCL10
Gene Full Name	B-cell lymphoma/leukemia 10
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl10, identical to the related rat and mouse sequences.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, NFKB Pathway, Nuclear Signaling, Pathways and Processes, Signal Transduction, Signaling Pathway
Protein Name	B-cell lymphoma/leukemia 10
Protein Function	Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Subcellular Localization	Cytoplasm, perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Description	Boster Bio Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody catalog # PA1504. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Ubiquitous.
Sequence Similarities	Contains 1 CARD domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1504-datasheet.pdf

BOS-PA1504-safety-datasheet.pdf