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Anti-Tenascin-R TNR Antibody

Anti-Tenascin-R TNR Antibody

Manufacturer	Boster
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Regulation of Appetite Molecular Targets for Neuroscience Antibodies Cell Biology Cell Status Necrosis Immunohistochemistry Western Blot Primary Antibodies Neurodegeneration Markers;Research Area Oncology By Organ Brain Cancer
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Isotype	IgG
Format	Lyophilized
Applications	WB, IHC
Amount	100 ug/vial
Host	Rabbit
Item no.	BOS-PA1695-1
Targets	TNR, TNC
eClass 6.1	32160702
eClass 9.0	32160702
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Axonal Guidance Proteins, Cell Adhesion Proteins, Cytoskeleton/ECM, Developmental Biology, ECM Proteins, Extracellular Matrix, Growth and Development, Nervous System Development, Neurology Process, Neuroscience, Organogenesis, Signal Transduction
Short Description	Boster Bio Anti-Tenascin-R TNR Antibody catalog # PA1695-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Tenascin-R TNR Antibody catalog # PA1695-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Tenascin-R is a protein that in humans is encoded by the TNR gene. Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR. The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues. TNR has been detected predominantly in the central nervous system and is localized around motor neurons and on motor axons in the spinal cord, cerebellum, hippocampus, and olfactory bulb. It is suggested that tenascin-R has a role in initiating the detachment of neuroblasts from tangential chains and in initiating radial migration of the cells.
Gene Name	TNR
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Rat, Human, Mouse, By Heat Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Application Notes	WB: The detection limit for TNR is approximately 3ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Chicken
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of mouse TNR, identical to the related rat sequence, and different from the related human sequence by one amino acid.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Tenascin-R
Molecular Weight	149562 MW
Protein Function	Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity)..
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Brain specific..
Protein Name	Tenascin-R(TN-R)
Sequence Similarities	Belongs to the tenascin family.

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