Manufacturer |
Boster
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Mouse, Rat |
Isotype |
IgG |
Format |
Lyophilized |
Applications |
WB, ELISA |
Amount |
100 ug/vial |
Host |
Rabbit |
Item no. |
BOS-A00478-3 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Cancer, Cytoskeleton/ECM, Developmental Biology, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells, Structures |
Short Description |
Boster Bio Anti-FGF23 Antibody Picoband™ catalog # A00478-3. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. |
Description |
Boster Bio Anti-FGF23 Antibody Picoband™ catalog # A00478-3. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. |
Background |
Fibroblast growth factor 23orFGF23is aproteinthat in humans is encoded by theFGF23gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). |
Gene Name |
FGF23 |
Application Details |
Western blot, 0.1-0.5μg/ml ELISA, 0.1-0.5μg/ml |
Clonality |
Polyclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Immunogen |
E. coli-derived rat FGF23 recombinant protein (Position: Y25-V251). |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene Full Name |
fibroblast growth factor 23 |
Molecular Weight |
35 kDa |
Protein Function |
Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. |
Subcellular Localization |
Secreted. |
Tissue Specificity |
Expressed in the parathyroid. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.