Manufacturer |
Boster
|
Category |
|
Type |
Antibody Primary |
Specific against |
Human |
Isotype |
IgG |
Format |
Liquid |
Applications |
FC |
Amount |
100 ug/vial |
Host |
Rabbit |
Item no. |
BOS-A01651-Dyl488 |
Conjugate/Tag |
DyLight 488 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Microbiology |
Short Description |
Boster Bio Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody catalog # A01651-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Human SCRIBBLE DyLight® 488 conjugated Antibody catalog # A01651-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Background |
SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis. |
Gene Name |
SCRIB |
Application Details |
Flow Cytometry, 1-3μg/1x106 cells |
Clonality |
Polyclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
Immunogen |
E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409). |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
Gene Full Name |
scribbled planar cell polarity protein |
Protein Function |
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. |
Subcellular Localization |
Cell membrane. |
Tissue Specificity |
Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.