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Anti-GABRB1(Ab-434) Antibody European Partner

Item no. BOS-A04752
Manufacturer Boster
Amount 100 ul
Category
Type Antibody
Format Liquid
Applications WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Gamma-aminobutyric acid receptor subunit beta-1;GABA (A) receptor subunit beta-1;GABRB1;
Available
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
54235 MW
Clonality
Polyclonal
Application Details
Predicted MW: 54kd

Western blotting: 1:500~1:1000
IHC 1:50-1:200
Manufacturer - Gene Name
GABRB1
Gene Full Name
Gamma-aminobutyric acid receptor subunit beta-1
Background
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding a 4, a 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
Collins AL, et al. (2006) Neurogenetics ; 7(3):167-174.
Ma DQ, et al. (2005) Am J Hum Genet ; 77(3):377-388.
Edenberg HJ, et al. (2004) Am J Hum Genet ; 74(4):705-714.
Immunogen
Peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1.
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/ml
Protein Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity).
Subcellular Localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Short Description
Boster Bio Anti-GABRB1(Ab-434) Antibody (Catalog # A04752). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Description
Boster Bio Anti-GABRB1(Ab-434) Antibody (Catalog # A04752). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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