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Anti-Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker) Monoclonal Antibody

Anti-Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker) Monoclonal Antibody

Manufacturer	Boster
Category	Food Safety Vitamines Neuroscience Neuroinflammation Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Specific against	Human
Clone	PDPN/1433
Isotype	IgG1 Kappa
Format	Liquid
Applications	IF, IHC, ELISA
Amount	100ug
Host	Mouse
Item no.	BOS-M01124
Targets	PDPN
eClass 6.1	32160702
eClass 9.0	42030590
Available
Manufacturers Product Category	Primary Antibodies, Monoclonal Antibodies
Manufacturers Research Category	Angiogenesis, Cardiovascular, Cell Type Markers, Tags & Cell Markers, Vasculature
Short Description	Boster Bio Anti-Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker) Monoclonal Antibody (Catalog # M01124). Tested in ELISA, IF, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-Podoplanin (PDPN) (Lymphatic Endothelial & Mesothelial Marker) Monoclonal Antibody (Catalog # M01124). Tested in ELISA, IF, IHC applications. This antibody reacts with Human.
Background	This monoclonal antibody recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.
Gene Name	PDPN
Clonality	Monoclonal
Concentration	Purified antibody with BSA and azide at 200ug/ml
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Application Details	ELISA (For coating, order antibody without BSA) Immunofluorescence (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Immunogen	Recombinant human Podoplanin (PDPN) protein fragment (around aa 24-126) (exact sequence is proprietary)
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Gene Full Name	Podoplanin
Molecular Weight	16698 MW
Protein Function	May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels..
Subcellular Localization	Cell Surface and Cytoplasmic
Tissue Specificity	Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas..

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 5/30/2024