Manufacturer |
Boster
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Lyophilized Powder |
Amount |
10ug |
Item no. |
BOS-PROTP56828 |
Targets |
MAPT |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Contents |
Lyophilized from (1mg/ml) solution containing PBS pH-7.4. |
Description |
Interferon-Tau Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton. The IFN-Tau is purified by proprietary chromatographic techniques. |
Gene name |
IFNT1 |
Protein function |
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. |
Purification |
Greater than 95.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Shipping |
Shipped with wet ice |
Short description |
Interferon-Tau Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton. The IFN-Tau is purified by proprietary chromatographic techniques. |
Storage |
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles. |
Subcellular localization |
Secreted. Secreted into the uterine lumen. |
Tissue specificity |
Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm. |
Format Information |
Sterile Filtered White lyophilized (freeze-dried) powder. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.