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MLF1 Myeloid Leukemia Factor 1 Human Recombinant Protein

MLF1 Myeloid Leukemia Factor 1 Human Recombinant Protein

Manufacturer	Boster
Category	Oncology By Cell Type Carcinoma Hematology Leukemia Lymphoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma By Organ Heart & Blood Cancer
Type	Proteins Recombinant
Specific against	other
Format	Solution
Amount	20ug
Item no.	BOS-PROTP58340
Targets	MLF1
eClass 6.1	34160400
eClass 9.0	42020190
Available
Contents	The MLF1 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 5mM DTT and 200mM NaCl.
Description	MLF1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 288 amino acids (1-268 a.a.) and having a molecular mass of 32.8kDa (Molecular weight on SDS-PAGE will appear higher). The MLF1 is purified by proprietary chromatographic techniques.
Gene name	MLF1
Protein function	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Purification	Greater than 85.0% as determined by SDS-PAGE.
Shipping	Shipped with wet ice
Short description	MLF32.8kDa (Molecular weight on SDS-PAGE will appear higher). The MLF1 is purified by proprietary chromatographic techniques.
Storage	Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Subcellular localization	Cytoplasm
Tissue specificity	Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Format Information	Sterile Filtered colorless solution.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20ug

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Delivery expected until 5/30/2024