« Back
Home /
IL-6R, Canine (HEK293, His)

IL-6R, Canine (HEK293, His)

Item no.	HY-P73221-20ug
Manufacturer	MedChem Express
Amount	20 ug
Quantity options	100 ug 10 ug 20 ug 2 ug 50 ug 5 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	96.50
Dry ice	Yes
Sequence	LAPWGCPAPE VMSGVVTSLP GASVTLTCPG GEPEDNGTVQ WLLQNLVDDS YLGSRAAVGR TLLLRSVQLS DSGNYSCYQD GRLAGTVRLL VDAPPEEPQL ACFRKSPLSM VFCEWSPRHP PSPKTRATLL VRKFRGRPVG DSQEPCPYAQ GPQKFSCQLA VPEGDNSLYV VSLCVTNSAG SRSSTPQTFE GYGILQPDPP VNITVTAVDR NPRWLRVSWQ DPPSWNSYFY RL
Citations	[1]Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70.\|[2]Malemud, et al. Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases. Curr Pharmacol Rep 4, 358-366.\|[3]Larsen JV, et al. SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 May 16;37(11):e00641-16.\|[4]Kang S, et al. Targeting Interleukin-6 Signaling in Clinic. Immunity. 2019 Apr 16;50(4):1007-1023.\|[5]Giannitrapani L, et al. Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma. Ann N Y Acad Sci. 2002 Jun;963:46-52.\|[6]Arnold P, et al. Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles. Cells. 2020 May 24;9(5):1307.\|[7]Mishra AK, et al. Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells. Leukemia. 2019 Nov;33(11):2695-2709.\|[8]Gruber CN, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020 Nov 12;183(4):982-995.e14.
Smiles	LAPWGCPAPE VMSGVVTSLP GASVTLTCPG GEPEDNGTVQ WLLQNLVDDS YLGSRAAVGR TLLLRSVQLS DSGNYSCYQD GRLAGTVRLL VDAPPEEPQL ACFRKSPLSM VFCEWSPRHP PSPKTRATLL VRKFRGRPVG DSQEPCPYAQ GPQKFSCQLA VPEGDNSLYV VSLCVTNSAG SRSSTPQTFE GYGILQPDPP VNITVTAVDR NPRWLRVSWQ DPPSWNSYFY RLQFELRYRA ERSKTFTMLM IKEFQHHCII HDAWRGMRHV VQLRAREEFG HGSWSTWSQE AVGTPWTESR SPAAETELPH STQAPTTNED NKNNISKDIA NATSLPVQDS SSAPLP
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-6R Protein,Canine (HEK293,His),Canine,HEK293
Shipping Condition	Dry ice
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Dry Ice
Storage Conditions	Stored at -80°C for 1 year
Molecular Weight	Approximately 39.8 kDa
Product Description	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway[1][2]. IL-6R alpha, Canine consists of 462 amino acids (M1-R462) and is produced in HEK293 cells with a C-Terminal His-tag.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 20 ug

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question