Rabbit Anti-Rat TLR4 Affinity Purified pAb

Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.

Rabbit Anti-Rat TLR4 Affinity Purified polyclonal antibody. TLR4 is a mammalian homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL1 receptor for signal transduction that leads to activation of NF-eB.

Synthetic peptide corresponding to residues surrounding amino acids 819 or rat TLR4

Recognizes ca.92 kDa rat TLR4