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Recombinant Human proIGF2 (aa 1-156) Receptor Grade

Recombinant Human proIGF2 (aa 1-156) Receptor Grade

Manufacturer	Cell Sciences
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite By Cell Type Carcinoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Endocrine Regulation of Lipid Metabolism
Type	Proteins
Specific against	Human
Amount	100 ug
Host	E.coli
Item no.	CS-AHU100
Targets	IGF2, IGF1, INS
eClass 6.1	34160400
eClass 9.0	42020190
Available
Biological Activity	Stimulation of protein synthesis in rat L6 myoblasts.
Description	Recombinant Human Insulin-like Growth Factor-II (Human IGF-II) is synthesized as a 156 amino acid precursor protein, known as proIGF-II. This protein includes an 87 amino acid C-terminal region known as the E-domain. A proteolysis step releases the mature 67 amino acid IGF-II polypeptide. The proIGF-II proteins make up 10-20% of circulating IGF-II. Pro-IGF-II proteins are secreted by some tumor cell lines and levels are elevated in non-islet cell tumor hypoglycemia.
Endotoxin Level	< 0.1 EU/ug
Formulation	Lyophilized white powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa)
Molecular Weight	The final product contains three major isoforms of proIGF-II corresponding to molecular weights of 16.1, 17.0 and 17.6 kDa. These species correspond to the full length 156 amino acid protein and two smaller species corresponding to C-terminal truncations of approximately 5 and 15 residues which result from the purification process
Reconstitution	Protocol #1000
Storage and Stability	This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

CS-AHU100.pdf

CS-AHU100-datasheet.pdf

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Amount: 100 ug

available

Delivery expected until 5/23/2024