Recombinant Human UBE2B

Biomolecules

This E2 enzyme encodes for the human homolog of the yeast DNA repair gene RAD6, which is induced by DNA damaging agents. UBE2B can conjugate ubiquitin to histone H2A in an E3- independent manner, in vitro , and is essential for the multi-ubiquitination and degradation of N-end rule substrates. Additionally, UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia. Ubiquitin Conjugating Enzyme E2B Human Recombinant produced in, E. coli, is a 19 kDa protein containing 166 amino acids. The UE2B protein contains 6xHis tag and is purified by proprietary chromatographic techniques.

It is recommended to reconstitute the lyophilized UBE2B in sterile water not less than 100ug/ml, which can then be further diluted to other aqueous solutions.