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Rabbit anti-human Thiopurine S-methyltransferase polyclonal Antibody

Rabbit anti-human Thiopurine S-methyltransferase polyclonal Antibody

Item no.	CSB-PA00585A0Rb
Manufacturer	Cusabio
Amount	100ug
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Thiopurine methyltransferase
Available
Uniprot ID	P51580
Immunogen	Recombinant human Thiopurine S-methyltransferase protein
Conjugate	Non-conjugated
Alias	Thiopurine methyltransferase
Relevance	TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Buffer	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Stroage	Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
Purity	Caprylic Acid Ammonium Sulfate Precipitation purified
Abbreviation	Thiopurine S-methyltransferase protein
Research Area	Metabolism
References	\"Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA.\""Honchel R., Aksoy I.A., Szumlanski C., Wood T.C., Otterness D.M., Wieben E.D., Weinshilboum R.M.Mol. Pharmacol. 43:878-887(1993)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 8/28/2025

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