« Back
Home /
Rabbit anti-human Histone deacetylase 3 polyclonal Antibody,Biotin conjugated

Rabbit anti-human Histone deacetylase 3 polyclonal Antibody,Biotin conjugated

Item no.	CSB-PA010239LD01HU
Manufacturer	Cusabio
Amount	100ug
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	HD3,RPD3-2,SMAP45,HDAC3
Available
Uniprot ID	O15379
Immunogen	Recombinant human Histone deacetylase 3 protein(1-428aa?
Conjugate	Biotin conjugated
Alias	HD3, RPD3-2, SMAP45, HDAC3
Relevance	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
Buffer	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Stroage	Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
Purity	Caprylic Acid Ammonium Sulfate Precipitation purified
References	"A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters." Hatzi K., Jiang Y., Huang C., Garrett-Bakelman F., Gearhart M.D., Giannopoulou E.G., Zumbo P., Kirouac K., Bhaskara S., Polo J.M., Kormaksson M., Mackerell A.D. Jr., Xue F., Mason C.E., Hiebert S.W., Prive G.G., Cerchietti L., Bardwell V.J., Elemento O., Melnick A. Cell Rep. 4:578-588(2013) .

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CSB-PA010239LD01HU-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100ug

available

Delivery expected until 10/16/2025

Compare

Add to wishlist

Get an offer

Request delivery time