LCK Antibody

LCK

IMD22 antibody; LCK antibody; Lck p56 antibody; LCK proto-oncogene; Src family tyrosine kinase antibody; LCK_HUMAN antibody; Leukocyte C-terminal Src kinase antibody; LSK antibody; Lymphocyte cell specific protein tyrosine kinase antibody; Lymphocyte cell-specific protein-tyrosine kinase antibody; Lymphocyte specific protein tyrosine kinase antibody; Membrane associated protein tyrosine kinase antibody; Oncogene lck antibody; P56 LCK antibody; p56(LSTRA) protein tyrosine kinase antibody; p56-LCK antibody; p56lck antibody; pp58 lck antibody; pp58lck antibody; Protein YT16 antibody; Proto oncogene tyrosine protein kinase LCK antibody; Proto-oncogene Lck antibody; Protooncogene tyrosine protein kinase LCK antibody; T cell specific protein tyrosine kinase antibody; T cell-specific protein-tyrosine kinase antibody; T lymphocyte specific protein tyrosine kinase p56lck antibody; Tyrosine-protein kinase Lck antibody; YT 16 antibody; YT16 antibody

Recombinant Human Tyrosine-protein kinase Lck protein (1-539AA)

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.

>95%, Protein G purified

Immunology

Recombinant Human Tyrosine-protein kinase Lck protein (1-539AA)