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Recombinant Human Leukemia inhibitory factor protein(LIF) (Active)

Recombinant Human Leukemia inhibitory factor protein(LIF) (Active)

Item no.	CSB-AP002221HU-500
Manufacturer	Cusabio
Amount	500 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human (Homo sapiens)
Purity	>98% as determined by SDS-PAGE and HPLC.
Sequence	SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQ LNGSANAL FILYYTAQGE PFPNNLDKLC GPNV TDFPPF HANGTEKAKL VELYRIVVYL GTSLGN ITRD QKILNPSALS LHSKLNATAD ILRGLLSN VL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Protein Family	LIF/OSM family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	LIF, D factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	19.7 kDa
General Research Areas	Immunology
Relevance	LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Function	LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Subcellular Location	Secreted
Paythway	Jak-STATsignalingpathway
Gene Names	LIF, HILDA
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	LIF_HUMAN
Expression Region	23-202aa
Protein Description	Full Length of Mature Protein
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 x 107 IU/mg.
PubMed ID	3143918; 2475312; 15146197; 1692837; 14702039; 10591208; 15489334; 3128791; 2730639; 8489250; 14527405; 17652170

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CSB-AP002221HU-500-datasheet.pdf

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Amount: 500 ug

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Delivery expected until 9/4/2025

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