« Back
Home /
Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein(TNFRSF1A) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein(TNFRSF1A) (Active)

Item no.	CSB-AP002361HU-500
Manufacturer	Cusabio
Amount	500 ug
Quantity options	1 mg 100 ug 20 ug 250 ug 5 ug 500 ug
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Conjugate/Tag	Tag Free
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQ NNSICCTK CHKGTYLYND CPGPGQDTDC RECE SGSFTA SENHLRHCLS CSKCRKEMGQ VEISSC TVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLC LN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor necrosis factor receptor 1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,p55
Available
Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Molecular Weight	21.2 kDa
Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
General Research Areas	Cancer
Relevance	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Expression Region	22-211aa
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Secreted, Note=A secreted form is produced through proteolytic processing, SUBCELLULAR LOCATION: Isoform 4: Secreted
Involvement in disease	Familial hibernian fever (FHF); Multiple sclerosis 5 (MS5)
Pathway	MAPKsignalingpathway
Gene Names	TNFRSF1A, TNFAR, TNFR1
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 ug/ml, corresponding to a specific activity of ? 2 x 104 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha.
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	TNR1A_HUMAN
Protein Description	Partial
PubMed ID	2158862; 2158863; 1702293; 1698610; 2170974; 1315717; 14702039; 19906316; 16541075; 15489334; 8015639; 2153136; 9557650; 10356400; 10542291; 10359574; 9915703; 15465831; 21976655; 22801493; 8387891; 8939750; 10199409; 10902757; 11443543; 13130484; 14610673

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CSB-AP002361HU-500-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 500 ug

available

Delivery expected until 11/13/2025

Express Delivery: Save 1 days

Compare

Add to wishlist

Get an offer