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Recombinant Human Platelet-derived growth factor subunit B protein(PDGFB) (Active)

Recombinant Human Platelet-derived growth factor subunit B protein(PDGFB) (Active)

Manufacturer	Cusabio
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human
Amount	500ug
Item no.	CSB-AP002631HU-500
eClass 6.1	34160400
eClass 9.0	42020190
Available
Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Cancer
Uniprot NO.	P01127
Uniprot Entry Name	PDGFB_HUMAN
Gene Names	PDGFB, PDGF2, SIS
Source	E.Coli
Expression Region	82-190aa
Sequence	M+SLGSLTIAE PAMIAECKTR TEVFEISRRL I DRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRP TQVQLRP VQVRKIEIVR KKPIFKKATV TLEDH LACKC ETVAAARPVT
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	24.8 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of ? 3.3 x 105 IU/mg.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	PDGF subunit B, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin
Relevance	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
PubMed ID	6740330; 4033772; 2991848; 3472769; 3517869; 15461802; 10591208; 15489334; 7659502; 8988177; 6327048; 3456904; 6306471; 6844921; 6329745; 1661670; 1317862; 11331882; 12660034; 18483217; 1396586; 20534510; 23913003
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin
Involvement in disease	Basal ganglia calcification, idiopathic, 5 (IBGC5)
Subcellular Location	Secreted
Protein Families	PDGF/VEGF growth factor family
Tissue Specificity	Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Paythway	Jak-STATsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CSB-AP002631HU-500-datasheet.pdf

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Amount: 500ug

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