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Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Active)

Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Active)

Item no.	CSB-AP002851HU-500
Manufacturer	Cusabio
Amount	500 ug
Quantity options	1 mg 10 ug 100 ug 250 ug 50 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human (Homo sapiens)
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RY LCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEA
Protein Family	Neuregulin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Pro-NRG1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	7.5 kDa
General Research Areas	Neuroscience
Relevance	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. {ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:7902537}.
Function	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4
Subcellular Location	Pro-neuregulin-1, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein, Note=Does not seem to be active, SUBCELLULAR LOCATION: Neuregulin-1: Secreted, SUBCELLULAR LOCATION: Isoform 8: Nucleus, Note=May be nuclear, SUBCELLULAR LOCATION: Isoform 9: Secreted, Note=Has a signal peptide, SUBCELLULAR LOCATION: Isoform 10: Membrane, Single-pass type I membrane protein
Tissue Specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.
Involvement in disease	A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8; 11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
Paythway	ErbBsignalingpathway
Gene Names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 m filtered 1 x PBS, pH 7.4, with 5 % trehalose , lyophilized
Uniprot Entry Name	NRG1_HUMAN
Expression Region	122-186aa
Protein Description	Partial of Isoform 11
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 x 106 IU/mg.
PubMed ID	1350381; 7509448; 8096067; 7782315; 14702039; 16421571; 9333014; 12145742; 17565985; 15489334; 7689552; 1348215; 7902537; 10523851; 10597312; 10867024; 8062828; 8639490

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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