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Recombinant Human Pleiotrophin protein(PTN) (Active)

Recombinant Human Pleiotrophin protein(PTN) (Active)

Item no.	CSB-AP002931HU-250
Manufacturer	Cusabio
Amount	250 ug
Quantity options	1 mg 100 ug 20 ug 250 ug 5 ug 500 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Skin Cancer Lymphatic System Cancer
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Conjugate/Tag	Tag Free
Purity	>96% as determined by SDSPAGE and HPLC.
Sequence	GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GL GTREGTRT GAECKQTMKT QRCKIPCNWK KQFG AECKYQ FQAWGECDLN TALKTRTGSL KRALHN AECQ KTVTISKPCG KLTKPKPQAE SKKKKKEG KK QEKMLD
Protein Family	Pleiotrophin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	PTN,HBBM,Heparin-binding growth factor 8,HBGF-8,Heparin-binding growth-associated molecule
Available
Manufacturer - Category	Cytokine / Growth Factor
Molecular Weight	15.3 kDa
Buffer	0.2 m filtered PBS, pH 7.4 , lyophilized
General Research Areas	Immunology
Relevance	Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269\|PubMed:11278720, ECO:0000269\|PubMed:1768439}.
Expression Region	33-168aa
Function	Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells
Subcellular Location	Secreted
Tissue Specificity	Osteoblast and brain.
Gene Names	PTN, HBNF1, NEGF1
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16ÂE18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been preÂcoated with 100 ul/well of a solution of 5Â10 ug/ml rHuPTN.
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	PTN_HUMAN
Protein Description	Full Length of Mature Protein
PubMed ID	1701634; 2270483; 1768439; 1457401; 8484754; 9299545; 14702039; 12690205; 15489334; 2388713; 1733956; 8241100; 8484780; 11278720; 20873783

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 ug

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Delivery expected until 2/12/2026

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