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Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein(TNFRSF11B) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein(TNFRSF11B) (Active)

Item no.	CSB-AP002991HU-1
Manufacturer	Cusabio
Amount	1 mg
Quantity options	1 mg 10 ug 100 ug 250 ug 50 ug 500 ug
Category	Oncology Peptides & Proteins Recombinant Proteins By Organ Lymphatic System Cancer
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Conjugate/Tag	Fc
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QH CTAKWKTV CAPCPDHYYT DSWHTSDECL YCSP VCKELQ YVKQECNRTH NRVCECKEGR YLEIEF CLKH RSCPPGFGVV QAGTPERNTV CKRCPDGF FS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQKCGIDVTL+ EPKSSDKTHT CPPCPAPEFE GAPSVFLFPP KPKDTLMISR TP EVT
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Osteoclastogenesis inhibitory factor,
Available
Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Manufacturer - Conjugate / Tag	C-terminal Fc-tagged
Molecular Weight	109.6 kDa
Buffer	0.2um filtered 20 mM PB, pH 6.0, 150 mM NaCl, 0.02 % Tween-80 , lyophilized
General Research Areas	Immunology
Relevance	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269\|PubMed:22664871, ECO:0000269\|PubMed:9168977}.
Expression Region	22-201aa
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Subcellular Location	Secreted
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Involvement in disease	Paget disease of bone 5, juvenile-onset (PDB5)
Pathway	Osteoclastdifferentiation
Gene Names	TNFRSF11B, OCIF, OPG
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of ? 1.0 x 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	TR11B_HUMAN
Protein Description	Partial
PubMed ID	9108485; 9492069; 9688283; 14702039; 16421571; 15489334; 9571159; 15340161; 12110935; 9168977; 9603945; 9478964; 11505389; 22664871; 12189164

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 2/12/2026

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