Comparison

Recombinant Human Proteasome subunit alpha type-1(PSMA1),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against other
Amount 50ug
Host E.coli
Item no. CSB-EP018865HU-50
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research Topic
Immunology
Uniprot ID
P25786
Gene Names
PSMA1
Organism
Homo sapiens (Human)
AA Sequence
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSAT VGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHI GISIAGLTADARLLCNFMRQECLDSRFVFDRPLPV SRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDM GPHIFQTCPSANYFDCRAMSIGARSQSARTYLERH MSEFMECNLNELVKHGLRALRETLPAEQDLTTKNV SIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQ PAQPAD
Expression Region
1-251aa
Sequence Info
Partial
Source
E.coli
Tag Info
N-terminal 6xHis-tagged
MW
32.2 kDa
Alternative Name
30KDA prosomal protein . PROS-30Macropain subunit C2Multicatalytic endopeptidase complex subunit C2. Proteasome component C2. Proteasome nu chain
Relevance
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome . Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells .
Reference
"N-terminome analysis of the human mitochondrial proteome."Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.Proteomics 15:2519-2524(2015)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular Location
Cytoplasm, Nucleus
Protein Families
Peptidase T1A family
Amount: 50ug
Available: In stock
Listprice: €227.63
Price: €227.63
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