« Back
Home /
Recombinant Human Neuroserpin protein(SERPINI1) (Active)

Recombinant Human Neuroserpin protein(SERPINI1) (Active)

Item no.	CSB-AP000141HU-100
Manufacturer	Cusabio
Amount	100 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Category	Food Safety Proteins Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Glial Cell Markers
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	TGATFPEEAI ADLSVNMYNR LRATGEDENI LF SPLSIALA MGMMELGAQG<br/>STQKEIRHSM GYDS LKNGEE FSFLKEFSNM VTAKESQYVM KIANSL FVQN<br/>GFHVNEEFLQ MMKKYFNAAV NHVDFSQN VA VANYINKWVE NNTNNLVKDL<br/>VSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK D DESEVQIPM<br/>MYQQGEFYYG EF
Protein Family	Serpin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Peptidase inhibitor 12, Serpin I1
Available
Manufacturer - Category	Enzyme / Enzyme
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	44.7 kDa
General Research Areas	Neuroscience
Relevance	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
Function	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin
Subcellular Location	Secreted, Cytoplasmic vesicle, secretory vesicle lumen, Perikaryon
Tissue Specificity	Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).
Involvement in disease	Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)
Gene Names	SERPINI1, PI12
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.5 , lyophilized
Uniprot Entry Name	NEUS_HUMAN
Expression Region	17-406aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2000 IU/mg.
PubMed ID	9070919; 14702039; 17974005; 15489334; 10517635

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CSB-AP000141HU-100-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ug

available

Delivery expected until 10/30/2025

Express Delivery: Save 3 days

Compare

Add to wishlist

Get an offer