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Recombinant Human Platelet basic protein(PPBP) (Active)

Recombinant Human Platelet basic protein(PPBP) (Active)

Item no.	CSB-AP000701HU-10
Manufacturer	Cusabio
Amount	10 ug
Quantity options	1 mg 10 ug 100 ug 2 ug 250 ug 500 ug
Category	Oncology Food Safety Proteins Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins By Organ Bladder Cancer
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CN QVEVIATL KDGRKICLDP DAPRIKKIVQ KKLA GDESAD
Protein Family	Intercrine alpha (chemokine CxC) family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	PBP, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF
Available
Manufacturer - Category	Cytokine / Chemokine
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	7.6 kDa
General Research Areas	Immunology
Relevance	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269\|PubMed:10877842, ECO:0000269\|PubMed:7890771, ECO:0000269\|PubMed:8950790, ECO:0000269\|PubMed:9794434}.
Function	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
Subcellular Location	Secreted
Paythway	Chemokinesignalingpathway
Gene Names	PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	CXCL7_HUMAN
Expression Region	59-128aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.
PubMed ID	2713489; 1826003; 11468158; 14702039; 15815621; 15489334; 2423119; 15340161; 10877842; 6572368; 12665801; 77677; 8950790; 2783111; 2522778; 7890771; 2406364; 2007144; 9794434; 24275569; 8034022; 7706245

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 10/30/2025

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