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Recombinant Human Oncostatin-M protein(OSM) (Active)

Recombinant Human Oncostatin-M protein(OSM) (Active)

Item no.	CSB-AP002251HU-2
Manufacturer	Cusabio
Amount	2 ug
Quantity options	1 mg 10 ug 100 ug 2 ug 250 ug 500 ug
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Peptides & Proteins Recombinant Proteins Glial Cell Markers
Type	Proteins Recombinant
Format	Solid
Specific against	other
Host	E.coli
Conjugate/Tag	Tag Free
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LD PYIRIQGL DVPKLREHCR ERPGAFPSEE TLRG LGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQ DLER SGLNIEDLEK LQMARPNILG LRNNIYCM AQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES P NRSRRHSPH QALRKGVRRT RPSRKGKRLM TRG QLP
Protein Family	LIF/OSM family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	OSM,
Available
Manufacturer - Category	Cytokine / Growth Factor
Molecular Weight	25.8 kDa
Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
General Research Areas	Immunology
Relevance	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250}.
Expression Region	26-252
Function	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Subcellular Location	Secreted
Pathway	Jak-STATsignalingpathway
Gene Names	OSM
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	ONCM_HUMAN
Protein Description	Partial
PubMed ID	2779549; 15461802; 10591208; 15489334; 3540948; 1542792; 2325640; 2026606; 1717982; 1542793; 8999038; 10997905

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 2 ug

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Delivery expected until 12/4/2025

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