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Recombinant Human Fibroblast growth factor 19(FGF19),partial(Active)

Recombinant Human Fibroblast growth factor 19(FGF19),partial(Active)

Item no.	CSB-AP002461HU-100
Manufacturer	Cusabio
Amount	100 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Neural Signaling Neural Adhesion Molecules Peptides & Proteins Recombinant Proteins Calcium Binding Protein Markers Interneuron Markers
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	M+RPLAFSDAG PHVHYGWGDP IRLRHLYTSG P HGLSSCFLR IRADGVVDCA RGQSAHSLLE IKA VALRTVA IKGVHSVRYL CMGADGKMQG LLQYS EEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSA KQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLR G HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK
Protein Family	Heparin-binding growth factors family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FGF-19,
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	21.8 kDa
General Research Areas	Cancer
Relevance	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269\|PubMed:12815072, ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:17623664, ECO:0000269\|PubMed:19085950}.
Function	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Subcellular Location	Secreted
Tissue Specificity	Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Paythway	MAPKsignalingpathway
Gene Names	FGF19, UNQ334/PRO533
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	FGF19_HUMAN
Expression Region	23-216aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of ? 6.7 x 103 IU/mg.
PubMed ID	9931477; 10525310; 12975309; 15489334; 15340161; 12815072; 16597617; 17623664; 18829467; 19085950; 20094046; 14730967; 17339340

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/18/2025

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