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Recombinant Human Insulin-like growth factor I protein(IGF1) (Active)

Recombinant Human Insulin-like growth factor I protein(IGF1) (Active)

Item no.	CSB-AP002521HU-100
Manufacturer	Cusabio
Amount	100 ug
Quantity options	1 mg 100 ug 20 ug
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SS RRAPQTGI VDECCFRSCD LRRLEMYCAP LKPA KSA
Protein Family	Insulin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IGF-I, MGF, Somatomedin-C
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	7.4 kDa
General Research Areas	Cancer
Relevance	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269\|PubMed:21076856, ECO:0000269\|PubMed:24132240}.
Function	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation
Subcellular Location	Secreted
Involvement in disease	Insulin-like growth factor I deficiency (IGF1 deficiency)
Paythway	HIF-1signalingpathway
Gene Names	IGF1, IBP1
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	IGF1_HUMAN
Expression Region	52-118aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
PubMed ID	6358902; 3002851; 2935423; 2937782; 3455760; 2082190; 2018498; 1372070; 8495408; 16541075; 15489334; 6382022; 632300; 3242681; 21076856; 24132240; 6189745; 2036417; 1319992; 8857020; 10391209

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CSB-AP002521HU-100-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 10/9/2025

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