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Recombinant Human Proepiregulin(EREG),partial (Active)

Recombinant Human Proepiregulin(EREG),partial (Active)

Item no.	CSB-AP002621HU-250
Manufacturer	Cusabio
Amount	250 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Category	Oncology Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins By Organ Bladder Cancer
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	VAQVSITKCS SDMNGYCLHG QCIYLVDMSQ NY CRCEVGYT GVRCEHFFL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	EPR,
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	5.6 kDa
General Research Areas	Cancer
Relevance	Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269\|PubMed:9419975}.
Function	Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation
Subcellular Location	Epiregulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Proepiregulin: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
Paythway	ErbBsignalingpathway
Gene Names	EREG
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	EREG_HUMAN
Expression Region	60-108aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
PubMed ID	9337852; 14702039; 15489334; 9419975; 14572630; 16959974

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 ug

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Delivery expected until 8/28/2025

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