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Recombinant Human Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein(HBEGF) (Active)

Recombinant Human Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein(HBEGF) (Active)

Item no.	CSB-AP002651HU-50
Manufacturer	Cusabio
Amount	50 ug
Quantity options	1 mg 10 ug 100 ug 250 ug 50 ug 500 ug
Category	Oncology Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Skin Cancer Bladder Cancer
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	DLQEADLDLL RVTLSSKPQA LATPNKEEHG KR KKKGKGLG KKRDPCLRKY KDFCIHGECK YVKE LRAPSC ICHPGYHGER CHGLSL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	HB-EGF, Diphtheria toxin receptor, DT-R,],
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	9.7 kDa
General Research Areas	Cancer
Relevance	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Function	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular Location	Heparin-binding EGF-like growth factor: Secreted, extracellular space
Paythway	ErbBsignalingpathway
Gene Names	HBEGF, DTR, DTS, HEGFL
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 20 mM PB, pH 7.4, 130 mM NaCl , lyophilized
Uniprot Entry Name	HBEGF_HUMAN
Expression Region	63-148aa
Protein Description	Full Length of Mature Protein
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of ? 1.0 x 106 IU/mg.
PubMed ID	1840698; 14702039; 15372022; 15489334; 1556128; 7836353; 9135143; 16508205; 22171320; 23234360; 9659904

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 9/25/2025

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