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Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein(BTC) (Active)

Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein(BTC) (Active)

Item no.	CSB-AP002871HU-100
Manufacturer	Cusabio
Amount	100 ug
Quantity options	1 mg 100 ug 20 ug 250 ug 5 ug 500 ug
Category	Oncology Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins By Organ Skin Cancer Bladder Cancer
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>98% as determined by SDS-PAGE and HPLC.
Sequence	DGNSTRSPET NGLLCGDPEE NCAATTTQSK RK GHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVC DEGYIG ARCERVDLFY
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	BTC,
Available
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	9.0 kDa
General Research Areas	Signal Transduction
Relevance	Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269\|PubMed:8570211}.
Function	Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular Location	Betacellulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Probetacellulin: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Paythway	ErbBsignalingpathway
Gene Names	BTC
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4, with 0.02 % Tween-20 , lyophilized
Uniprot Entry Name	BTC_HUMAN
Expression Region	32-111aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 x 107 IU/mg.
PubMed ID	8439318; 15489334; 8144591; 8919026; 8570211; 10867024; 12074582

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CSB-AP002871HU-100-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 9/25/2025

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