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Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein(MANF) (Active)

Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein(MANF) (Active)

Item no.	CSB-AP002891HU-100
Manufacturer	Cusabio
Amount	100 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TI ENELIKFC REARGKENRL CYYIGATDDA ATKI INEVSK PLAHHIPVEK ICEKLKKKDS QICELK YDKQ IDLSTVDLKK LRVKELKKIL DDWGETCK GC AEKSDYIRKI NELMPKYAPK AASARTDL
Protein Family	ARMET family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Arginine-rich protein,
Available
Manufacturer - Category	Others / Others
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	18.2 kDa
General Research Areas	Neuroscience
Relevance	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269\|PubMed:12794311, ECO:0000269\|PubMed:18561914}.
Function	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
Subcellular Location	Secreted
Gene Names	MANF, ARMET, ARP
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	MANF_HUMAN
Expression Region	25-182aa
Protein Description	Full Length of Mature Protein
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 ug/ml, corresponding to a specific activity of ? 50 IU/mg.
PubMed ID	8649854; 15489334; 16641997; 12665801; 12794311; 15144186; 18561914; 21269460; 24275569; 19258449; 8971156; 9174057

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/4/2025

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