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Recombinant Human Multidrug resistance-associated protein 1 (ABCC1),partial

Recombinant Human Multidrug resistance-associated protein 1 (ABCC1),partial

Item no.	CSB-EP001056HU-1
Manufacturer	Cusabio
Amount	1 mg
Quantity options	1 mg 10 ug 100 ug 20 ug 200 ug 50 ug 500 ug
Category	Oncology Food Safety Hormones Peptides & Proteins Recombinant Proteins By Organ Lung Cancer
Type	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	Greater than 90% as determined by SDS-PAGE.
Sequence	VRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTI NGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEII IDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMN LDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE CAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIM DYT
Protein Family	ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Citations	Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G. Science 258:1650-1654(1992)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter
Available
Manufacturer - Targets	ABCC1
Manufacturer - Conjugate / Tag	N-terminal 6xHis-tagged
Storage Conditions	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight	35.9 kDa
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
General Research Areas	Signal Transduction
Relevance	Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Biologically Active	Not Test
Expression Region	1248-1531aa
Protein Length	Partial
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Subcellular Location	Cell membrane, Multi-pass membrane protein
Tissue Specificity	Lung, testis and peripheral blood mononuclear cells.
Paythway	Sphingolipidsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 10/30/2025

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