Comparison

Recombinant Human natriuretic peptide B (NPPB),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against other
Format Liquid
Amount 50ug
Host E.coli
Item no. CSB-EP016021HU(A5)-50
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research Topic
Signal Transduction
Uniprot ID
P16860
Gene Names
NPPB
Organism
Homo sapiens (Human)
AA Sequence
DLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESP
Expression Region
37-71aa
Sequence Info
Partial
Source
E.coli
Tag Info
N-terminal GST-tagged
MW
31 kDa
Alternative Name
Gamma-brain natriuretic peptide
Relevance
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Reference
"Human and canine gene homologs of porcine brain natriuretic peptide."
Seilhamer J.J., Arfsten A., Miller J.A., Lundquist P., Scarborough R.M., Lewicki J.A., Porter J.G.
Biochem. Biophys. Res. Commun. 165:650-658(1989)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Subcellular Location
Secreted
Protein Families
Natriuretic peptide family
Tissue Specificity
Brain and also in atria, but at much lower levels than ANP.
Paythway
cGMP-PKGsignalingpathway
Amount: 50ug
Available: In stock
Listprice: €227.63
Price: €227.63
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