Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
200ug |
Item no. |
CSB-EP335461EFB1-200 |
Conjugate/Tag |
Myc |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Others |
Uniprot ID |
P29362 |
Gene Names |
LMP1 |
Organism |
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4) |
AA Sequence |
YYHGPRHTDEHHHDDSLPHPQQATDDSSHESDSNS NEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQ DPDNTDDNGPQDPDNTDDNGPQDPDNTDDNGPQDP DNTDDNGPQDPDNTDDNGPQDPDNTDDNGPQDPDN TDDNGPHDPLPHSPSDSAGNDGGPPNLTEEVANKG GDRGPPSMTDGGGGDPHLPTLLLGTSGSGGDDDDP HGPVQLSYYD |
Expression Region |
185-404aa |
Sequence Info |
Partial |
Source |
E.coli |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
MW |
29.8 kDa |
Alternative Name(s) |
Protein p63 |
Relevance |
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It is a short-lived protein probably degraded by the proteasome |
Reference |
"Evolutionarily conserved herpesviral protein interaction networks." Fossum E., Friedel C.C., Rajagopala S.V., Titz B., Baiker A., Schmidt T., Kraus T., Stellberger T., Rutenberg C., Suthram S., Bandyopadhyay S., Rose D., von Brunn A., Uhlmann M., Zeretzke C., Dong Y.A., Boulet H., Koegl M.Haas J. PLoS Pathog. 5:e1000570-e1000570(2009) |
Purity |
Greater than 85% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It is a short-lived protein probably degraded by the proteasome (By similarity). |
Subcellular Location |
Host cell membrane, Multi-pass membrane protein |
Protein Families |
Herpesviridae LMP-1 family |
Tag Information |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.