Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
200ug |
Host |
E.coli |
Item no. |
CSB-RP040044h-200 |
Conjugate/Tag |
GST |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Metabolism |
Uniprot ID |
Q9Y4W6 |
Gene Names |
AFG3L2 |
Organism |
Homo sapiens (Human) |
AA Sequence |
ERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWY LEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKE QLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVT QSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPY SEATARLIDDEVRILINDAYKRTVALLTEKKADVE KVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEF |
Expression Region |
550-759aa |
Sequence Info |
Partial |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
50.8 kDa |
Alternative Name(s) |
Paraplegin-like protein |
Relevance |
ATP-dependent protease which is essential for axonal development. |
Reference |
Identification and characterization of AFG3L2, a novel paraplegin-related gene.Banfi S., Bassi M.T., Andolfi G., Marchitiello A., Zanotta S., Ballabio A., Casari G., Franco B.Genomics 59:51-58(1999) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU |
Involvement in disease |
Spinocerebellar ataxia 28 (SCA28); Spastic ataxia 5, autosomal recessive (SPAX5) |
Subcellular Location |
Mitochondrion, Mitochondrion inner membrane, Multi-pass membrane protein |
Protein Families |
AAA ATPase family; Peptidase M41 family |
Tissue Specificity |
Ubiquitous. Highly expressed in the cerebellar Purkinje cells. |
Tag Information |
N-terminal GST-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.