Recombinant Human G-protein coupled receptor 161(GPR161),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Amount 1mg
Host E.coli
ArtNr CSB-RP041144h-1
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research Topic
Signal Transduction
Uniprot ID
Q8N6U8
Gene Names
GPR161
Organism
Homo sapiens (Human)
AA Sequence
MSLNSSLSCRKELSNLTEEEGGEGGVII
Expression Region
1-28aa
Sequence Info
Partial
Tag Info
N-terminal GST-tagged
MW
30 kDa
Alternative Name(s)
G-protein coupled receptor RE2
Relevance
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .
Reference
Isolation of cDNA coding for G-protein coupled receptor RE2.Warren C.N., Aronstam R.S., Sharma S.V. Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone.Raming K., Konzelmann S., Breer H.Recept. Channels 6:141-151(1998)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 1mg
Available: In stock
Listprice: €1,246.43
Price: €1,246.43
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