Recombinant Human Glutamate carboxypeptidase 2(FOLH1),partial

Cancer

Not Test

Homo sapiens (Human)

EATNITPKHNMKAFLDELKAENIKKFLYNFTQIPH LAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLL SYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYE NVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFK LERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGA KGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGN ILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSI PVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPY NVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTL RGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHE IVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGST EWAEENSRLLQERGVAYINADSSIEGNYTLRVDCT PLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSP SPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARY TKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKY HLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKY ADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEI ASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFID PLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDAL FDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLS EVA

48-750aa

83.1 kDa

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Greater than 90% as determined by SDS-PAGE.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Isoform PSMA': Cytoplasm

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.