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CPSF4 Polyclonal Antibody

CPSF4 Polyclonal Antibody

Item no.	E-AB-14891-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Adenocarcinoma Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	cleavage and polyadenylation specific factor 4, 30kDa, Cleavage and polyadenylation specificity factor 30 kDa subunit, Cleavage and polyadenylation specificity factor subunit 4, cleavage polyadenylation specificity factor, 30kD, CPSF 30 kDa subunit, CPSF30, Cpsf4, CPSF4, NAR, Neb-1, NEB1, No arches homolog, no arches like zinc finger protein, NS1 effector domain binding protein 1, NS1 effector domain-binding protein 1, OTTHUMP00000206235, OTTHUMP00000206237, OTTHUMP00000206239
Similar products	CPSF4, Cpsf4, CPSF30, NAR, NEB1, 30kD, 30kDa, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, Neb-1, No arches homolog, cleavage and polyadenylation specific factor 4, cleavage polyadenylation specificity factor, no arches like zinc finger protein, NS1 effector domain binding protein 1, OTTHUMP00000206235, OTTHUMP00000206237, OTTHUMP00000206239
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	CPSF4
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	30kDa
Research Areas	Epigenetics and Nuclear Signaling, Microbiology
Background	Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Concentration	0.4 mg/mL
Buffer	PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000
Santa Cruz #	sc-79418, sc-79417, sc-133480
Abbreviation	CPSF4
Clonality	Polyclonal
Immunogen	Recombinant protein of human CPSF4
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.