Comparison

NOTCH1 Polyclonal Antibody

Item no. E-AB-62151-60
Manufacturer Elabscience
Amount 60 uL
Quantity options 120 uL 200 uL 60 uL
Category
Type Antibody Polyclonal
Applications WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias hN1, Neurogenic locus Notch homolog protein 1, NICD, NOTC1, Notch 1, Notch 1 intracellular domain, Notch homolog 1 translocation associated (Drosophila), notch1, TAN1, Translocation-associated notch protein TAN-1
Similar products Notch 1, hN1, Translocation-associated notch protein TAN-1, TAN1, notch1, NICD, Notch 1 intracellular domain, Neurogenic locus Notch homolog protein 1, NOTC1, Notch homolog 1 translocation associated (Drosophila)
Available
Storage Conditions
Store at -20C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
272kDa
Observed Molecular Weight
300kDa
Manufacturer - Research Areas
Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental Biology, Neuroscience, Stem Cells
Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Concentration
1 mg/mL
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4
Purification Method
Affinity purification
Recommended Dilution
WB1:500 - 1:2000 IHC1:100 - 1:200
Immunogen
A synthetic peptide of human NOTCH1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 60 uL
Available: In stock
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