beta-NGF ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human beta-NGF. The Human beta-NGF ELISA is for research use only. Not for diagnostic or therapeutic procedures. Nerve growth factor (NGF) is initially in a complex of 3 proteins - alpha-NGF, beta-NGF, and gamma-NGF when expressed. This form of NGF is also referred to as proNGF (NGF precursor). The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating the protein into functional NGF. The term "Nerve Growth Factor" usually refers to the beta subunit of the protein. NGF is a neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. NGF appears to promote myelin repair. Hence NGF may be useful for the treatment of multiple sclerosis. NGF could also be involved in various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Dysregulation of NGF signaling has also been linked to Alzheimer's disease.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

0.78 pg/ml

85 % - 115 %

n.d. - 138.7 pg/ml

3.0 % - 7.0 %