PI3 Kinase p85 alpha antibody, pAb, Rabbit

USA

GenScript, PI3 Kinase p85 alpha Antibody, detects endogenous levels of human PI3 Kinase p85 alpha. Predicted to react with mouse and rat PI3 Kinase p85 alpha according to sequence homology. Positive Control: Ramos

Phosphoinositide 3-kinase (PI3K) catalyzes the phosphatidylinositol-3, 4, 5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP), and phosphatidylinositol-4, 5-bisphosphate (PIP2). PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit (p85). The catalytic subunits of PI3K include p110 alpha, p110 beta, p110 gamma, and p110 delta, while the regulatory subunits contain p85 alpha and p85 beta. p85 alpha regulates the catalytic activity of p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain. The p85 alpha has been implicated in insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.GenScript, PI3 Kinase p85 alpha Antibody, is developed in rabbit using a KLH-coupled synthetic peptide within residues 600–650 of human PI3 Kinase p85 alpha (Swiss Prot: P27986).

Immunoaffinity chromatography

85 KD