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PTH (1-84aa), Human

PTH (1-84aa), Human

Item no.	Z02021-10
Manufacturer	GenScript
Amount	10 ug
Category	Oncology Food Safety By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cytoskeleton Cardiovascular Research Thrombosis & Hemostasis Contaminants Microfilaments Metals By Organ Breast Cancer Heart & Blood Cancer Thyroid Cancer
Type	Proteins
Specific against	Human
Purity	Greater than 98.0% as determined by: 1. Analysis by RP-HPLC 2. Anion-exchange FPLC 3. Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel
Citations	Gessi M, et al . Parathyroid hormone-related peptide (hPTHrP) and parathyroid hormone-related peptide receptor type 1 (PTHR1) expression in human thymus. J. Histochem. Cytochem. Aug 2005, 53(8): 955-962. Huan J, et al . Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands. J. Am. Soc. Nephrol. Jul 2006, 17(7): 1923-1930. Mahon MJ, Segre GV. Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J. Biol. Chem. May 2004, 279(22): 23550-23558.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02021_10-Parathyroid_Hormone_PTH_1_84_Human,Parathyroid Hormone (PTH), is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. Parathyroid Hormone (PTH) is secreted from cells of the parathyroid glands and finds Parathyroid Hormone's major target cells in bone and kidney. Like most other protein hormones, Parathyroid Hormone (PTH) is synthesized as a preprohormone. After intracellular processing, the mature hormone is packaged within the Golgi into secretory vesicles, the secreted into blood by exocytosis. Parathyroid Hormone (PTH) is secreted as a linear protein of 84 amino acids. Recombinant, Human Parathyroid Hormone (PTH), produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 84 amino acids and having a molecular mass of 9,000 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 9,000 Da</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 98.0% as determined by: 1. Analysis by RP-HPLC 2. Anion-exchange FPLC 3. Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1 ng/ug (1 EU/ug) of Human Parathyroid Hormone (PTH) .</td></tr><tr><th>Specific Activity</th><td colspan="7"> PTH is fully biologically active when compared to standards. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 1.0×104 U/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized, Human Parathyroid Hormone (PTH ), remains stable at room temperature for three weeks, but it is best stored desiccated below -18C. Upon reconstitution Human Parathyroid Hormone (PTH )should be stored at 4C for up to seven days. For long term storage it is recommended that a carrier protein (0.1% HSA or BSA ) be added. Avoid repeated freeze-thaw cycles.</td></tr><tr><th>Formulation</th><td colspan="7"> The protein (1 mg/ml) was lyophilized after extensive dialyses against 1.15 mg sodium citrate, sodium chloride 7.31 mg, 0.21 mg citric acid, 0.1117 mg EDTA-Na2, 0.2 mg Tween 80 and 50 mg Mannitol.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended to reconstitute the lyophilized PTH in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.</td></tr><tr><th>Reference</th><td colspan="7">Gessi M, et al . Parathyroid hormone-related peptide (hPTHrP) and parathyroid hormone-related peptide receptor type 1 (PTHR1) expression in human thymus. J. Histochem. Cytochem. Aug 2005, 53(8): 955-962. Huan J, et al . Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands. J. Am. Soc. Nephrol. Jul 2006, 17(7): 1923-1930. Mahon MJ, Segre GV. Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J. Biol. Chem. May 2004, 279(22): 23550-23558.</td></tr>
Similar products	Parathyroid
Available
Specificity	PTH is fully biologically active when compared to standards. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 1.0x104 U/mg.
Specificity	PTH is fully biologically active when compared to standards. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 1.0x104 U/mg.
Description	Parathyroid Hormone (PTH), is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. Parathyroid Hormone (PTH) is secreted from cells of the parathyroid glands and finds Parathyroid Hormone's major target cells in bone and kidney. Like most other protein hormones, Parathyroid Hormone (PTH) is synthesized as a preprohormone. After intracellular processing, the mature hormone is packaged within the Golgi into secretory vesicles, the secreted into blood by exocytosis. Parathyroid Hormone (PTH) is secreted as a linear protein of 84 amino acids. Recombinant, Human Parathyroid Hormone (PTH), produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 84 amino acids and having a molecular mass of 9, 000 Da.
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) of Human Parathyroid Hormone (PTH) .
Formulation	The protein (1 mg/ml) was lyophilized after extensive dialyses against 1.15 mg sodium citrate, sodium chloride 7.31 mg, 0.21 mg citric acid, 0.1117 mg EDTA-Na2, 0.2 mg Tween 80 and 50 mg Mannitol.
M.W.	9, 000 Da
Product Line	Cytokine, Chemokines & Growth Factors
Reconstitution	It is recommended to reconstitute the lyophilized PTH in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage	Lyophilized, Human Parathyroid Hormone (PTH ), remains stable at room temperature for three weeks, but it is best stored desiccated below -18C. Upon reconstitution Human Parathyroid Hormone (PTH )should be stored at 4C for up to seven days. For long term storage it is recommended that a carrier protein (0.1% HSA or BSA ) be added. Avoid repeated freeze-thaw cycles.
Manufacturers Category	Proteins
Manufacturers Product Line	Hormones
Product Origin	USA

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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