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TSLP, Human

TSLP, Human

Item no.	Z02721-10
Manufacturer	GenScript
Amount	10 ug
Quantity options	1 mg 10 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Neural Transcription Factors By Cell Type Hematology Leukemia Lymphoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Obesity Cell Culture Cytokines Cardiovascular Research Ischemia & Reperfusion Injury By Organ Heart & Blood Cancer Testicular & Prostate Cancer
Type	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Specific against	Human (Homo sapiens)
Purity	>98% by SDS-PAGE and HPLC analyses.
Sequence	MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC L EQVSQLQG L WRRFNRPL LK QQ
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02721-Thymic_Stromal_Lymphopoietin_TSLP_Human, TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rª) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFª) while down-regulating IL-10 and IFN-I³ suggesting a role in initiating allergic inflammation.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 15.0 KDa, a single non-glycosylated polypeptide chain containing 132 amino acids.</td></tr><tr><th>Purity</th><td colspan="7"> >98% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuTSLP as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 as measured by its ability to induce proliferation of human IL-7Rª and human TSLP R co-transfected mouse BaF3 cells is less than 0.3 ng/ml,corresponding to a specific activity of > 3.3×106 units/mg.</td></tr><tr><th>Storage</th><td colspan="7"> This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized from a 0.2&
Similar products	Thymic
Shipping Condition	Cool pack
Available
Specificity	Fully biologically active when compared to standard. The ED50 as measured by its ability to induce proliferation of human IL-7Rª and human TSLP R co-transfected mouse BaF3 cells is less than 0.3 ng/ml,corresponding to a specific activity of > 3.3x106 unit
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	Approximately 15.0 KDa, a single non-glycosylated polypeptide chain containing 132 amino acids.
Product Line	Cytokines
Manufacturer - Specificity	Fully biologically active when compared to standard. The ED50 as measured by its ability to induce proliferation of human IL-7Rª and human TSLP R co-transfected mouse BaF3 cells is less than 0.3 ng/ml, corresponding to a specific activity of > 3.3x106 units/mg.
Description	TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rª) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFª) while down-regulating IL-10 and IFN-I³ suggesting a role in initiating allergic inflammation.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2µ, m filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.
Endotoxin Level	Less than 0.2EU/ug of rHuTSLP as determined by LAL method.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 8/7/2025

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