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Angiostatin K1-3, Human

Angiostatin K1-3, Human

Item no.	Z02730-50
Manufacturer	GenScript
Amount	50 ug
Quantity options	10 ug 50 ug
Category	Food Safety Proteins Neuroscience Neural Lineage Markers Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Specific against	Human (Homo sapiens)
Purity	>95% by SDS-PAGE and HPLC analyses.
Sequence	VYLSECKTGN, GKNYRGTMSK, TKNGITCQKW, SSTSPHRPRF, SPATHPSEGL, EENYCRNPDN, DPQGPWCYTT, DPEKRYDYCD, ILECEEECMH, CSGENYDGKI, SKTMSGLECQ, AWDSQSPHAH, GYIPSKFPNK, NLKKNYCRNP, DRELRPWCFT, TDPNKRWELC, DIPRCTTPPP, SSGPTYQCLK, GTGENYRGNV, AVTVSGHTCQ, HWSAQTPHTH, NRT
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02730-Angiostatin_K1-3_Human, Angiostatin K1-3 is a ca.30 kDa fragment of plasminogen that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Recombinant angiostatin is expressed in E. coli.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 30.0 KDa, a single non-glycosylated polypeptide chain containing 259 amino acids.</td></tr><tr><th>Purity</th><td colspan="7"> >95% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuAngiostatin as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells, in vitro, and anti-angiogenesis, in vivo, is 5.5×105 IU/mg.</td></tr><tr><th>Storage</th><td colspan="7"> This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized from a 0.2um filtered concentrated solution in 20mM NaAc, pH5.5, 4% mannitol.</td></tr><tr><th>Reconstitution</th><td colspan="7"> We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 C. Further dilutions should be made in appropriate buffered solutions.</td></tr><tr><th>Physical Appearance</th><td colspan="7"> Sterile Filtered White lyophilized (freeze-dried) powder.</td></tr><tr><th>Usage</th><td colspan="7"> This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.</td></tr><tr><th>Sequence</th><td colspan="7"> VYLSECKTGN, GKNYRGTMSK, TKNGITCQKW, SSTSPHRPRF, SPATHPSEGL, EENYCRNPDN, DPQGPWCYTT, DPEKRYDYCD, ILECEEECMH, CSGENYDGKI, SKTMSGLECQ, AWDSQSPHAH, GYIPSKFPNK, NLKKNYCRNP, DRELRPWCFT, TDPNKRWELC, DIPRCTTPPP, SSGPTYQCLK, GTGENYRGNV, AVTVSGHTCQ, HWSAQTPHTH, NRTPENFPCK, NLDENYCRNP, DGKRAPWCHT, TNSQVRWEYC, KIPSCDSSP</td></tr>
Similar products	Angiostatin
Available
Specificity	Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells, in vitro, and anti-angiogenesis, in vivo, is 5.5x105 IU/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Storage Conditions	This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Approximately 30.0 KDa, a single non-glycosylated polypeptide chain containing 259 amino acids.
Product Line	Others
Manufacturer - Specificity	Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells, in vitro, and anti-angiogenesis, in vivo, is 5.5x105 IU/mg.
Description	Angiostatin K1-3 is a ca.30 kDa fragment of plasminogen that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Recombinant angiostatin is expressed in E. coli.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in 20mM NaAc, pH5.5, 4% mannitol.
Endotoxin Level	Less than 0.2EU/ug of rHuAngiostatin as determined by LAL method.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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