GOAT ANTI HUMAN PI3-KINASE p110 SUBUNIT ALPHA

PI3-KINASE p110 SUBUNIT ALPHA

TRIS buffered saline pH7. 3

Synthetic peptide C-HQWLKDKNKGEIYD from the internal region of human PI3-kinase p110 subunit alpha (NP_006209. 2).

Phosphorylates PtdIns PtdIns4P and PtdIns(4 5)P2 with a preference for PtdIns(4 5)P2. Catalytic activityATP + 1-phosphatidyl-1D-myo-inositol 4 5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3 4 5-trisphosphate. Subunit structureHeterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 By similarity. Interacts with RASD2 By similarity. Involvement in diseaseDefects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms even of late-stage disease are vague. Consequently most patients are diagnosed with advanced disease. Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550]. Ref. 14Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined light brown flat macules. The lesions may be sparse or numerous. As they initially grow they develop a velvety to finely verrucous surface followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance. Ref. 19Sequence similaritiesBelongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain.